Treatment of Organs with Advanced Medicine
is Often Limited
is Often Limited
Effectiveness
of advanced medicines:
The ability to target therapeutics to the organs and to balance the exposure at the site of action against other compartments of the body can often not be guaranteed.
Technologies
applied:
Technologies for direct organ delivery are limited by safety, procedural complexity, or inability to achieve homogenous organ exposure.
Therapeutics
used:
High potency therapeutics often need to achieve high local levels of drug throughout the tissue which is limited by mode of delivery.
Patients
restrictions:
Advanced medicines are often given to patients with multiple comorbidities which increases the risk of systemic exposure.
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